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Signal-recognition particle

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A signal-recognition particle or SRP is a cytosolic particle that transiently binds:

  1. To the ER signal sequence in a nascent protein
  2. To the large ribosomal unit
  3. To the SRP receptor

SRP and its receptor initiate the transfer of the nascent chain across the ER membrane. Once the chain reaches the translocon, SRP and its receptor dislocate.


Components

  • P54
  • P9
  • P14
  • P68
  • P72
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