P27 cis-regulatory element

P27 cis-regulatory element
P27 cis-regulatory element
Identifiers
Other data
PDB structures	PDBe

The p27 cis-regulatory element is a structured G/C rich RNA element located in the 5' UTR discovered in the human p27 mRNA. This element contributes to cell cycle regulated translation and when deleted leads to a 50% drop in regulation. The element is thought to be able to form several different structures with similar free energy. It has been suggested that proteins may only bind to a specific structure thus conformational changes could regulate translation.^[1]

References

^ Gopfert, U (2003). "Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF". Hum Mol Genet. 12: 1767–1779. doi:10.1093/hmg/ddg177. PMID 12837699. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

External links

Page for p27 cis-regulatory element at Rfam

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[1] Gopfert, U (2003). "Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF". Hum Mol Genet. 12: 1767–1779. doi:10.1093/hmg/ddg177. PMID 12837699. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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