Receptor activity-modifying protein

Receptor activity-modifying protein 2
Receptor activity-modifying protein 2
Identifiers
Symbol	RAMP2
NCBI gene	10266
HGNC	9844
OMIM	605154
RefSeq	NM_005854
UniProt	O60895
Other data
Locus	Chr. 17 q12-21.1
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

Receptor activity-modifying protein 1
Receptor activity-modifying protein 1
Identifiers
Symbol	RAMP1
NCBI gene	10267
HGNC	9843
OMIM	605153
RefSeq	NM_005855
UniProt	O60894
Other data
Locus	Chr. 2 q36-37.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Receptor activity-modifying protein 3

Identifiers

Symbol

Other data

Chr. 7 q13-p12

Search for
Structures	Swiss-model
Domains	InterPro

Receptor activity-modifying proteins (RAMPs) are a class of protein which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).^[1] There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.^[2]

Association of RAMPs with either the CT or CALCRL proteins form 6 different receptors from the calcitonin receptor family ^[3].

CALCRL...:^[4]^[5]

+ RAMP1: produces a CGRP receptor
+ RAMP2: produces an adrenomedullin (AM) receptor, designated AM₁^[6]
+ RAMP3: produces a dual CGRP/AM receptor, designated AM₂

CT... :

+ RAMP1: produces the amylin receptor AMY₁
+ RAMP2: produces the amylin receptor AMY₂
+ RAMP3: produces the amylin receptor AMY₃

External links

"Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
Receptor+activity+modifying+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

^ Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). "Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs". Ann N Y Acad Sci. 1070: 90–104. doi:10.1196/annals.1317.076. PMID 16888151.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Young A (2005). "Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology". Advances in Pharmacology. 52: 47–65. doi:10.1016/S1054-3589(05)52003-9. PMID 16492540.
^ *"Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ Foord SM, Marshall FH (1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609. {{cite journal}}: Unknown parameter |month= ignored (help)
^ Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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[Sexton-1] Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). "Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs". Ann N Y Acad Sci. 1070: 90–104. doi:10.1196/annals.1317.076. PMID 16888151.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[Young-2] Young A (2005). "Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology". Advances in Pharmacology. 52: 47–65. doi:10.1016/S1054-3589(05)52003-9. PMID 16492540.

[IUPHAR-DB-3] *"Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)

[pmid9620797-4] McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[pmid10354609-5] Foord SM, Marshall FH (1999). "RAMPs: accessory proteins for seven transmembrane domain receptors". Trends Pharmacol. Sci. 20 (5): 184–7. doi:10.1016/S0165-6147(99)01347-4. PMID 10354609. {{cite journal}}: Unknown parameter |month= ignored (help)

[pmid10217420-6] Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T (1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS Lett. 448 (1): 111–4. doi:10.1016/S0014-5793(99)00358-0. PMID 10217420. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

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