Captopril challenge test
In medicine, the captopril challenge test, also CCT, is a non-invasive test used to help diagnose renal artery stenosis. It should not be confused with the captopril suppression test.
The CCT, in adults, has a high sensitivity, but a low specificity.[1] A better test for diagnosing renal artery stenosis is renal subtraction angiography.[2]
How it is done
The CCT is performed by measuring the (plasma) renin prior to and following the administration of captopril, an angiotensin converting enzyme inhibitor. A CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high.[3]
Use of the CCT in children
The CCT has not been found to be very useful in children.[4]
Relation to captopril suppression test
The CCT should not be confused with the captopril suppression test,[5][6] a test used to diagnose primary aldosteronism (Conn syndrome).
The challenge test looks for a problem with the renal artery (stenosis). The suppression test looks for a problem related to the adrenal gland (over production of a mineralocorticoids).
References
- ^ Bales A. Hypertensive crisis. How to tell if it's an emergency or an urgency. Postgrad Med. 1999 May 1;105(5):119-26, 130. PMID 10335324. Free Full Text.
- ^ Svetkey LP, Himmelstein SI, Dunnick NR, Wilkinson RH Jr, Bollinger RR, McCann RL, Beytas EM, Klotman PE. Prospective analysis of strategies for diagnosing renovascular hypertension. Hypertension. 1989 Sep;14(3):247-57. PMID 2670763.
- ^ Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, Preibisz JJ, Laragh JH. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986 Apr;80(4):633-44. PMID 3515933.
- ^ Gauthier B, Trachtman H, Frank R, Pillari G. Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents. Pediatr Nephrol. 1991 Jan;5(1):42-4. PMID 2025535.
- ^ Racine MC, Douville P, Lebel M (2002). "Functional tests for primary aldosteronism: value of captopril suppression". Curr. Hypertens. Rep. 4 (3): 245–9. PMID 12003708.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Agharazii M, Douville P, Grose JH, Lebel M (2001). "Captopril suppression versus salt loading in confirming primary aldosteronism". Hypertension. 37 (6): 1440–3. PMID 11408392.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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