Modified Maddrey's discriminant function
Discriminant function (also called modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott[1] to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:
![{\displaystyle \left[{4}.{6}\times \ prothombin\ time\ -\ control\ value\ (seconds)\right]\ +\ serum\ bilirubin\ (mg/dl)\,}](/media/api/rest_v1/media/math/render/svg/ff3849147f66cdd7ab4a4f9852f9e303a0344a44)
Prospective studies have shown that, it is useful in predicting short term prognosis especially mortality within 30 days[2]. A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%[3].
To calculate Maddrey discriminant function using SI units - micromol/l (ie not US) divide bilirubin value by 88.4
See also
Reference list
- ^ Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI (1978). "Corticosteroid therapy of alcoholic hepatitis". Gastroenterology. 75 (2): 193–9. PMID 352788.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Sheth M, Riggs M, Patel T (2002). "Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis". BMC gastroenterology. 2: 2. PMID 11835693.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O (2000). "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial". Gastroenterology. 119 (6): 1637–48. PMID 11113085.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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