Multicenter Automatic Defibrillator Implantation Trial
MADIT (Multicenter Automatic Defibrillator Implantation Trial)
MADIT II is an ICD trial which investigates whether prophylactic implantable cardioverter defibrillator (ICD) therapy in moderately high-risk coronary patients — in addition to conventional therapy — would significantly reduce death compared with patients treated with conventional therapy alone.
The trial started in 1997 and ended in 2001 where the safety committee stopped the study because the benefits were statistically insignificant.
The study included patients with a prior myocardial infarction and an ejection fraction less than or equal to 30%.
The results were an reduction in mortality of 31% compared to patients receiving conventional therapy alone.
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