Multi-component reaction
In chemistry, a multi-component reaction (or MCR) is a chemical reaction where three or more compounds react to form a single product.[1]
Examples of three component reactions:
- Alkyne trimerisation
- Biginelli reaction
- Bucherer-Bergs reaction
- Gewald reaction
- Hantzsch pyridine synthesis
- Kabachnik-Fields Reaction
- Mannich reaction
- Passerini reaction
- Pauson-Khand reaction
- Strecker amino acid synthesis
Examples of four component reactions:
The exact nature of this type of reaction is often difficult to assess, in collision theory a simultaneous interaction of 3 or more different molecules is less likely resulting in a low reaction rate. These reactions are more likely to involve a series of bimolecular reactions.
New MCR's are found by building a chemical library from combinatorial chemistry or by combining existing MCR's.[2] For example, a 7-component MCR results from combining the Ugi reaction with the Asinger reaction.[3] MCR's are an important tool in new drug discovery.
See also
- A tandem reaction is a consecutive series of intramolecular organic reactions.
References
- ^Armstrong1996 Armstrong, R. W.; Combs, A. P.; Tempest, P. A.; Brown, S. D.; Keating, T. A. Acc. Chem. Res. 1996, 29, 123-131.
- ^ Recent progress in the chemistry of multicomponent reactions Ivar Ugi Pure Appl. Chem. 2001, 73, 187-191. (Online article)
- ^ The discovery of new isocyanide-based multi-component reactions Alexander Dömling Current Opinion in Chemical Biology 2000, 4, 318-323. (Online article)