Long non-coding RNA
There are a number of large non-coding RNAs in eukaryotes. These RNAs are mRNA-like (Pol II, spliced and polyadenylated) and perform regulatory roles.[1][2] Several have been characterised:
- Xist and TSIX regulate X chromosome inactivation
- AIR and H19 are paternal and maternal imprited genes which repress Igfr2 and igf2 on their respecive clusters, respectively
- HOTAIR transcribed from HOXC cluster inhibits late HOXD
- Evf
- CTN
- PINK
References
- ^ Erdmann VA, Szymanski M, Hochberg A, Groot N, Barciszewski J (2000). "Non-coding, mRNA-like RNAs database Y2K". Nucleic Acids Res. 28 (1): 197–200. PMID 10592224.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Hüttenhofer A, Schattner P, Polacek N (2005). "Non-coding RNAs: hope or hype?". Trends Genet. 21 (5): 289–97. doi:10.1016/j.tig.2005.03.007. PMID 15851066.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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