ATP synthase delta/OSCP subunit

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2a7uB:7-135 1abv :7-106 2bo5A:37-143

ATP synthase delta (OSCP) subunit
ATP synthase delta (OSCP) subunit
Identifiers
Symbol	OSCP
Pfam	PF00213
InterPro	IPR000711
PROSITE	PDOC00327
SCOP2	1abv / SCOPe / SUPFAM
TCDB	3.A.2
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	2a7uB:7-135 1abv :7-106 2bo5A:37-143

File:ATPsynthase labelled.png

Structure of ATP synthase, the F₀ proton channel and rotating stalk are shown in blue, the F₁ synthase domain in red and the membrane in grey.

ATP synthase delta subunit is a subunit of bacterial and chloroplast ATPase, or OSCP (oligomycin sensitivity conferral protein) in mitochondrial ATPase (note that in mitochondria there is a different delta subunit, InterPro: IPR001469).

The OSCP/delta subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex. In mitochondria, the peripheral stalk consists of OSCP, as well as F0 components F6, B and D. In bacteria and chloroplasts the peripheral stalks have different subunit compositions: delta and two copies of F0 component B (bacteria), or delta and F0 components B and B (chloroplasts)^[1].

Human delta subunit of ATP synthase is coded by gene ATP5O.

References

^ Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA (2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPaseand how it binds an alpha-subunit". J. Mol. Biol. 351 (4): 824–838. PMID 16045926.{{cite journal}}: CS1 maint: multiple names: authors list (link)

References

Further reading