Flap structure-specific endonuclease 1

FEN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
Identifiers
Aliases	FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
External IDs	OMIM: 600393; MGI: 102779; HomoloGene: 3034; GeneCards: FEN1; OMA:FEN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.2 Start 61,792,911 bp End 61,797,238 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 10,176,496 bp End 10,181,533 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte amniotic fluid paraflocculus of cerebellum gingival epithelium secondary oocyte tendon of biceps brachii gonad trabecular bone bone marrow embryo Top expressed in Paneth cell ciliary body primitive streak retinal pigment epithelium fetal liver hematopoietic progenitor cell iris cumulus cell endothelial cell of lymphatic vessel maxillary prominence motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA-DNA hybrid ribonuclease activity hydrolase activity, acting on ester bonds nuclease activity hydrolase activity double-stranded DNA binding catalytic activity damaged DNA binding double-stranded DNA exodeoxyribonuclease activity protein binding DNA binding endonuclease activity exonuclease activity 5'-3' exonuclease activity 5'-flap endonuclease activity flap endonuclease activity magnesium ion binding manganese ion binding Cellular component mitochondrion nucleus membrane nucleoplasm nucleolus protein-containing complex Biological process double-strand break repair via homologous recombination double-strand break repair memory cellular response to DNA damage stimulus UV protection DNA replication DNA repair RNA phosphodiester bond hydrolysis, endonucleolytic DNA replication, removal of RNA primer positive regulation of sister chromatid cohesion nucleic acid phosphodiester bond hydrolysis telomere maintenance via semi-conservative replication base-excision repair apoptotic DNA fragmentation retina development in camera-type eye Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2237 14156 Ensembl ENSG00000168496 ENSMUSG00000024742 UniProt P39748 P39749 RefSeq (mRNA) NM_004111 NM_001271614 NM_001271615 NM_007999 RefSeq (protein) NP_004102 n/a Location (UCSC) Chr 11: 61.79 – 61.8 Mb Chr 19: 10.18 – 10.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Flap structure-specific endonuclease 1, also known as FEN1, is a human gene.