4-chlorobenzoate dehalogenase

In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + H₂O $\rightleftharpoons$ 4-hydroxybenzoate + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoate and H₂O, whereas its two products are 4-hydroxybenzoate and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.

References

• Muller R, Thiele J, Klages U, Lingens F (1984). "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochem. Biophys. Res. Commun. 124: 178–82. PMID 6497878.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Heppel LA and Porterfield VT (1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds". J. Biol. Chem. 176: 763–769.

External links

The CAS registry number for this enzyme class is Template:CAS registry.