Codeinone reductase (NADPH)

In enzymology, a codeinone reductase (NADPH) (EC 1.1.1.247) is an enzyme that catalyzes the chemical reaction

codeine + NADP⁺ $\rightleftharpoons$ codeinone + NADPH + H⁺

Thus, the two substrates of this enzyme are codeine and NADP⁺, whereas its 3 products are codeinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is codeine:NADP+ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

References

• Lenz R and Zenk MH (1995). "Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum". Tetrahedron Lett. 36: 2449–2452.
• Lenz R, Zenk MH (1995). "Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants". Eur. J. Biochem. 233: 132–9. PMID 7588736.

External links

The CAS registry number for this enzyme class is Template:CAS registry.