Linoleate 11-lipoxygenase

In enzymology, a linoleate 11-lipoxygenase (EC 1.13.11.45) is an enzyme that catalyzes the chemical reaction

linoleate + O₂ $\rightleftharpoons$ (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate

Thus, the two substrates of this enzyme are linoleate and O₂, whereas its product is (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is linoleate:oxygen 11S-oxidoreductase. This enzyme is also called linoleate dioxygenase, manganese lipoxygenase. This enzyme participates in linoleic acid metabolism.

References

• Hamberg M, Su C, Oliw E (1998). "Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction". J. Biol. Chem. 273: 13080–8. PMID 9582346.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Oliw EH, Su C, Skogstrom T, Benthin G (1998). "Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn". Lipids. 33: 843–52. PMID 9778131.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Su C, Oliw EH (1998). "Manganese lipoxygenase. Purification and characterization". J. Biol. Chem. 273: 13072–9. PMID 9582345.