Dimethyl pimelimidate
Dimethyl pimelimidate dihydrochloride (IUPAC systematic name: 1,7-dimethoxyheptane-1,7-diimine dihydrochloride) (often abbreviated as DMP), is an organic chemical compound with two functional imine groups, which both bind to free amino groups at pH range 7.0-10.0 to form amidine bonds.
Uses
DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.
Health effects
Dimethyl pimelimidate (DMP) is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.
References
- MSDS safety data, also available in other languages
- [1]
- Another MSDS datasheet