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Hepatitis C alternative reading frame stem-loop

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Hepatitis C alternative reading frame stem-loop
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PDB structuresPDBe

The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures [1]. The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication [1]. The two predicted stem loops included in this model (SLV and SLVI) are proposed to be important for HCV translation and repression [1]. These stem loops are located downstream of the IRES site but their functional role is unknown [1].

References

  • [1] McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD,Feinstone SM, Rice CM; (2007). "Evidence for a functional RNA element in the hepatitis C virus coregene". Proc Natl Acad Sci U S A. 104: 2879–2884. PMID 17299041.{{cite journal}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link)
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