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Sequence assembly

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In bioinformatics, sequence assembly refers to aligning and merging fragments of a sequence to reconstruct the original sequence, typically fragments of the genome resulting from shotgun sequencing, or fragments of a gene transcript (ESTs).

Popular sequence assemblers are Phrap and CAP3, Phrap is very fast assembler, while CAP3 is slower, but generally considered more accurate.

References

www.phrap.org

Huang, X and Madan, A. (1999). CAP3: A DNA sequence assembly program. Genome Research,9:868-877.

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