Domine Database
 | The CorenSearchBot has performed a web search with the contents of this page, and it appears to include material copied directly from:
It will soon be reviewed to determine if there are any copyright issues. The content should not be mirrored or otherwise reused until the issue has been resolved. If substantial content is duplicated, unless evidence is provided to the contrary (e.g. evidence of permission to use this content under terms consistent with the Wikimedia Terms of Use or public domain status; see Wikipedia:Donating copyrighted materials), editors will assume that this text is a copyright violation, and will soon delete the copy.
Before removing this notice, you should:
|
DOMINE is a free and publicly available database of known and predicted protein domain interactions (or domain-domain interactions). It contains interactions inferred from PDB entries, and those that are predicted by 8 different computational approaches using Pfam domain definitions.
DOMINE Contents
DOMINE contains a total of 20,513 domain-domain interactions (among 4,036 domain) out of which 4,349 are inferred from PDB entries, and 17,781 are predicted by at least one computational approach. Of the 17,781 computational predictions, 3,143 interactions are classified as high-confidence predictions (predicted using multiple sources of information or by at least two sufficiently different approaches), 730 interactions are classified as medium-confidence predictions (those in which both domains are a part of the same biological process, as per GO terms), and the remaining 13,908 are classified as low-confidence predictions.
References
Printed
- B. Raghavachari, A. Tasneem, T.M. Przytycka, R. Jothi (2008). DOMINE: a database of protein domain interactions. Nucleic Acids Research 36(Database issue).