Histone 3′ UTR stem-loop

Histone 3′ UTR stem-loop
Identifiers
Other data
PDB structures	PDBe

The mRNAs of metazoan histone genes lack a poly-A tail. 3' end processing occurs at a site between a highly conserved stem-loop and a purine rich region around 20 nucleotides downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex. The Histone 3' UTR stem-loop is also involved in nucleocytoplasmic transport of the mRNA, and in stability regulation and translation efficiency in the cytoplasm.

References

• [1] Williams, AS (1995). "The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein". Nucleic Acids Res. 23: 654–662. PMID 7899087. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
• [2] Dominski, Z (1999). "Formation of the 3' end of histone mRNA". Gene. 239: 1–14. PMID 10571029. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

External link

• Page for Histone 3' UTR stem-loop at Rfam