Histone 3′ UTR stem-loop

Histone 3′ UTR stem-loop
Identifiers
Other data
PDB structures	PDBe

The mRNAs of metazoan histone genes lack a poly-A tail. 3' end processing occurs at a site between a highly conserved stem-loop (modelled by this family) and a purine rich region around 20 nts downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleate s the formation of the processing complex. The histone 3' UTR stem-loop is also involved in nucleocytoplasmic transport of the mRNA, and in stability regulation and translation efficiency in the cytoplasm.

References

• [1] Williams, AS (1995). "The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein". Nucleic Acids Res. 23: 654–662. PMID 7899087. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
• [2] Dominski, Z (1999). "Formation of the 3' end of histone mRNA". Gene. 239: 1–14. PMID 10571029. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

External link

• Page for Histone 3' UTR stem-loop at Rfam