Multicenter Automatic Defibrillator Implantation Trial

MADIT (Multicenter Automatic Defibrillator Implantation Trial)

MADIT II is an ICD trial which investigates whether prophylactic implantable cardioverter defibrillator (ICD) therapy in moderately high-risk coronary patients — in addition to conventional therapy — would significantly reduce death compared with patients treated with conventional therapy alone.

The trial started in 1997 and ended in 2001 where the safety comitee stopped the study becauswe the benefit where statistacal significant.

The study included patients with a prior myocardial infarction and an ejection fraction less than or equal to 30%.

The result were an reduction in mortality of 31% compared to patients receiving convntional therapy alone.