Lin-4 microRNA precursor

Lin-4 microRNA precursor
Identifiers
Other data
PDB structures	PDBe

This family represents the microRNA (miRNA) lin-4 (MIPF0000303). lin-4 was identified from a study of developmental timing in C. elegans [1], and was later shown to be part of a much larger class of non-coding RNAs termed miRNAs [2]. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference.

References

• [1] Rougvie, AE (2001). "Control of developmental timing in animals". Nat Rev Genet. 2: 690–701. PMID 11533718.
• [2] Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107: 823–826. PMID 11779458.

External links

• Page for lin-4 microRNA precursor at Rfam
• MIPF0000303