Cis-acting replication element
Background on Cis-acting replication elements (Cre)
Cis-acting replication elements (cre) bring together the 5′ and 3′ ends during replication of positive-sense single-stranded RNA viruses (for example Picornavirus, Flavivirus, Coronavirus, Togaviruses, Hepatitis C virus) and double-stranded RNA viruses (for example rotavirus and reovirus).[1]
Cis-acting replication elements (cre) are regions of the viral RNA that act as regulatory signals for essential steps in the virus life cycle[2]. These regions typically fold into loop-like structures and are located in the protein-making part of the genome called the translated region or flanking these regions in parts of the genome called the untranslated region [2][3].
These folded RNA structures interact with proteins from the virus or host to manage processes like making new viral proteins and replicating the virus’ genetic material [4]. The exact shape and role of these structures vary between different types of viruses [4].
See also
- Cis-regulatory element
- List of cis-regulatory RNA elements
- Enterovirus cis-acting replication element and Enterovirus 5′ cloverleaf cis-acting replication element
- Cardiovirus cis-acting replication element (CRE)
- Coronavirus SL-III cis-acting replication element (CRE)
- Rotavirus cis-acting replication element
- Hepatitis C virus cis-acting replication element
- Flavivirus 3′ UTR cis-acting replication element (CRE)
- Potato virus X cis-acting regulatory element
- Human rhinovirus internal cis-acting regulatory element (CRE)
- ^ Cordey, S; Gerlach, D; Junier, T; Zdobnov, EM; Kaiser, L; Tapparel, C (2008). "The cis-acting replication elements define human enterovirus and rhinovirus species". RNA. 14 (8): 1568–1578. doi:10.1261/rna.1031408. PMC 2491478. PMID 18541697.
- ^ a b Ríos-Marco, Pablo; Romero-López, Cristina; Berzal-Herranz, Alfredo (2016-05-11). "The cis-acting replication element of the Hepatitis C virus genome recruits host factors that influence viral replication and translation". Scientific Reports. 6 (1). doi:10.1038/srep25729. ISSN 2045-2322. PMC 4863150. PMID 27165399.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Cordey, Samuel; Gerlach, Daniel; Junier, Thomas; Zdobnov, Evgeny M.; Kaiser, Laurent; Tapparel, Caroline (2008-08). "The cis -acting replication elements define human enterovirus and rhinovirus species". RNA. 14 (8): 1568–1578. doi:10.1261/rna.1031408. ISSN 1355-8382. PMC 2491478. PMID 18541697.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link) - ^ a b Liu, Ying; Wimmer, Eckard; Paul, Aniko V. (2009-09-01). "Cis-acting RNA elements in human and animal plus-strand RNA viruses". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. Structure and Function of Regulatory RNA Elements. 1789 (9): 495–517. doi:10.1016/j.bbagrm.2009.09.007. ISSN 1874-9399. PMC 2783963. PMID 19781674.
{{cite journal}}: CS1 maint: PMC format (link)
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