Cis-acting replication element
Background on Cis-acting replication elements
Cis-acting replication elements bring together the 5′ and 3′ ends during replication of positive-sense single-stranded RNA viruses (for example Picornavirus, Flavivirus, Coronavirus, Togaviruses, Hepatitis C virus) and double-stranded RNA viruses (for example rotavirus and reovirus).[1]
Cre are regions of the viral RNA that act as regulatory signals for essential steps in the virus life cycle. These regions typically fold into loop-like structures and are located in the protein-making part of the genome called the translated region or flanking these regions in parts of the genome called the untranslated region .
These folded RNA structures interact with proteins from the virus or host to manage processes like making new viral proteins and replicating the virus’ genetic material . The exact shape and role of these structures vary between different types of viruses.
See also
- Cis-regulatory element
- List of cis-regulatory RNA elements
- Enterovirus cis-acting replication element and Enterovirus 5′ cloverleaf cis-acting replication element
- Cardiovirus cis-acting replication element (CRE)
- Coronavirus SL-III cis-acting replication element (CRE)
- Rotavirus cis-acting replication element
- Hepatitis C virus cis-acting replication element
- Flavivirus 3′ UTR cis-acting replication element (CRE)
- Potato virus X cis-acting regulatory element
- Human rhinovirus internal cis-acting regulatory element (CRE)
References
- ^ Cordey, S; Gerlach, D; Junier, T; Zdobnov, EM; Kaiser, L; Tapparel, C (2008). "The cis-acting replication elements define human enterovirus and rhinovirus species". RNA. 14 (8): 1568–1578. doi:10.1261/rna.1031408. PMC 2491478. PMID 18541697.
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