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Transporter associated with antigen processing

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transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
SymbolTAP1
Alt. symbolsABCB2
NCBI gene6890
HGNC43
OMIM170260
RefSeqNM_000593
UniProtQ03518
Other data
LocusChr. 6 p21.3
Search for
StructuresSwiss-model
DomainsInterPro
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
SymbolTAP2
Alt. symbolsABCB3
NCBI gene6891
HGNC44
OMIM170261
RefSeqNM_000544
UniProtQ03519
Other data
LocusChr. 6 p21.3
Search for
StructuresSwiss-model
DomainsInterPro

Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family (ABC transporter).[1] It delivers cytosolic peptides into the endoplasmic reticulum (ER) where they bind to nascent MHC class I molecules. [2]

Tapasin may also have a role in stablising "empty" MHC class 1 molecules (i.e. those without peptides destined for presentation), epitope selection and quality control after peptide binding.

References

  1. ^ Daumke, O. (2001) Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains. Eur. J. Biochem., 268:4776-4786.
  2. ^ Suh, WK. (1994) Interaction of MHC class I molecules with the transporter associated with antigen processing. Science. Vol 264 5163:1322-1326.
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