User:Turtleumd123/Neurobiological effects of physical exercise
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Clinical and preclinical evidence indicates that consistent aerobic exercise, especially endurance exercise (e.g., marathon running), prevents the development of certain drug addictions and is an effective adjunct treatment for drug addiction, and psychostimulant addiction. Consistent aerobic exercise magnitude-dependently (i.e., by duration and intensity) reduces drug addiction risk, which appears to occur through the reversal of drug-induced, addiction-related neuroplasticity. One review noted that exercise may prevent the development of drug addiction by altering ΔFosB or c-Fos immunoreactivity in the striatum or other parts of the reward system. Aditionally, aerobic exercise decreases psychostimulant self-administration, reduces the reinstatement (i.e., relapse) of drug-seeking, and induces opposite effects on striatal dopamine receptor D2 (DRD2) signaling (increased DRD2 density) to those induced by pathological stimulant use (decreased DRD2 density). Consequently, consistent aerobic exercise may lead to better treatment outcomes when used as an adjunct treatment for drug addiction. As of 2016, more clinical research is still needed to understand the mechanism and confirm the efficacy of exercise in drug addiction treatment and prevention.
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Exercise impacts the body in multiple ways and increases the blood flow throughout the human body. Exercise plays a huge role in strengthening both your muscles and bones. Exercise stimulates brain activity and also activates the nervous system. The nervous system is one of the body's most important functions because of its ability to regulate every process in the body. Exercise benefits the central nervous system by increasing blood flow, reducing inflammation, and stimulating the release of growth factors. https://www.health.harvard.edu/blog/regular-exercise-changes-brain-improve-memory-thinking-skills-201404097110