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Nuclear localization sequence

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In Genetics or Proteomics a Nuclear localizing signal (NLS) is a peptide "tag" on the exposed surface of a protein that interacts with nuclear membrane proteins to confine the polypeptide to the nucleus. Different nuclear localized proteins may share the same NLS.

Genetically the NLS results from transcription of a Nuclear localizing sequence. Cellular processes and protein function may be studied by adding a known NLS sequence to a gene, confining the chimeric protein product to the nucleus.

A NLS is the opposite of a Nuclear export signal, which confines proteins to the cytosolic face of the nuclear membrane.


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