From Wikipedia, the free encyclopedia
Human identical sequence (HIS) is RNA elements of 24-27nt length in coronavirus genomes shared sequence similarity within human genome ,[ 1] NamiRNAs (nuclear activating miRNAs) in viral progression.[ 2] SARS-CoV-2 genome, which have five HIS elements, other human coronavirus have one to five.[ 1]
SARS-CoV-2
name
sequence
location in virus genome
location in human genome
neighboring genes
note
HIS-SARS2-1
UGUCUAUGCUAAUGGAGGUAAAGGCU
7570-7595
Chr3 : 124017420-124017395KALRN
HIS-SARS2-2
UAUAACACAUATAAAAAUACGUGU
12494-12517
Chr3 : 176597319-176597342
HIS-SARS2-3
UUAUAUGCCUUAUUUCUUUACUUU
6766-6789
Chr5 : 28949255-28949232
HIS-SARS2-4
AGGAGAAUGACAAAAAAAAAAAAAAAA
29860-29886
Chr18 : 73670168-73670142FBXO15 , TIMM21 , CYB5A same as HIS-SARS1-2
HIS-SARS2-5
UUGUUGCUGCUAUUUUCUAUUUAA
8610-8633
ChrX : 99693480-99693457
SARS-CoV-1
name
sequence
location in virus genome
location in human genome
neighboring genes
note
HIS-SARS-1
HAS2 , ZHX2
HIS-SARS-2
AGGAGAAUGACAAAAAAAAAAAAAAAA
29717-29733
Chr18 : 73670168-73670142same as HIS-SARS2-4
MERS-CoV
HCoV-HKU1
HCoV-NL63
HCoV-OC43
HCoV-229E
References
^ a b Li, W; Yang, S; Xu, P; Zhang, D; Tong, Y; Chen, L; Jia, B; Li, A; Lian, C; Ru, D; Zhang, B; Liu, M; Chen, C; Fu, W; Yuan, S; Gu, C; Wang, L; Li, W; Liang, Y; Yang, Z; Ren, X; Wang, S; Zhang, X; Song, Y; Xie, Y; Lu, H; Xu, J; Wang, H; Yu, W (February 2022). "SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network". EBioMedicine . 76 : 103861. doi :10.1016/j.ebiom.2022.103861 . PMID 35124429 . ^ Yang, S; Ling, Y; Zhao, F; Li, W; Song, Z; Wang, L; Li, Q; Liu, M; Tong, Y; Chen, L; Ru, D; Zhang, T; Zhou, K; Zhang, B; Xu, P; Yang, Z; Li, W; Song, Y; Xu, J; Zhu, T; Shan, F; Yu, W; Lu, H (18 March 2022). "Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression". Signal transduction and targeted therapy . 7 (1): 91. doi :10.1038/s41392-022-00952-w . PMID 35304437 .
