Mycobacterium orygis
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Mycobacterium orygis is a species of the tuberculosis complex of the genus Mycobacterium. It causes tuberculosis in Oryx, Rhinos, dairy cattle, rhesus monkeys, and humans.
Morphology[edit]
Mycobacterium orygis is similar in morphology to species in the tuberculosis complex of Mycobacterium. It is a non-motile, acid fast bacteria. The cell walls are composed primarily of Mycolic acids. The cells are irregular rods, 0.3-0.5 um in diameter and 2-3 um in length.[1]
Metabolism[edit]
Mycobacterium orygis is an obligate aerobe, and a facultative intracellular pathogen. It has a doubling time of 15-20 hours within cells, and longer when outside cells. Mycobacterium orygis uses the host's cells internal fatty acids for both a carbon source and an energy source. These molecules include cholesterol, triacylglycerides, and glycosphingolipids. The optimum growing range for this sepcies is 32 degrees celcius.[1][2]
Genome[edit]
Strain 51145, obtained from a human diagnosed with tuberculosis meningitis in 1997, has a 4.4 Mbp genome, 4032 genes and a GC content of 65.6%.[3]
Causative agent of tuberculosis
This species is a pathogen of Oryx, deer, dairy cattle, rhesus monkeys, and humans. It is internationally spread as of 2021. It is a threat to the species greater one-horned rhinoceros, which is considered vulnerable by the ICUN. It can present as respiratory and neurological disease, and forms granulomas which can cause severe health problems and death.[4]
- ^ a b "Tuberculosis". textbookofbacteriology.net. Retrieved 2021-10-11.
- ^ van Ingen, J., Rahim, Z., Mulder, A., Boeree, M. J., Simeone, R., Brosch, R., & van Soolingen, D. (2012). Characterization of Mycobacterium orygis as M. tuberculosis Complex Subspecies. Emerging Infectious Diseases, 18(4), 653–655. https://doi-org.proxy.consortiumlibrary.org/10.3201/eid1804.110888
- ^ Rufai, S. et al. Complete Genome Sequence of Mycobacterium orygis strain 51145. American Society for Microbiology: https://journals.asm.org/doi/10.1128/MRA.01279-20
- ^ David M. Love, Michael M. Garner, Konstantin P. Lyashchenko, Alina Sikar-Gang, Daniel S. Bradway, Suelee Robbe-Austerman, Michele Miller, and Jan Ramer "TUBERCULOSIS CAUSED BY MYCOBACTERIUM ORYGIS IN A GREATER ONE-HORNED RHINOCEROS (RHINOCEROS UNICORNIS): FIRST REPORT IN THE WESTERN HEMISPHERE," Journal of Zoo and Wildlife Medicine 50(4), 1000-1004, (9 January 2020). https://doi.org/10.1638/2018-0084