Mesoderm development LRP chaperone

MESD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I9S, 2KGL, 2KMI, 2RQK, 2RQM, 3OFH
Identifiers
Aliases	MESD, BOCA, MESDC2, mesoderm development candidate 2, mesoderm development LRP chaperone, OI20
External IDs	OMIM: 607783; MGI: 1891421; HomoloGene: 11347; GeneCards: MESD; OMA:MESD - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,989,828 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	83,901,532 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; pancreatic ductal cell; ; corpus epididymis; ; mucosa of ileum; ; nasal epithelium; ; tibia; ; palpebral conjunctiva; ; parotid gland; ; internal globus pallidus; ; germinal epithelium;
	Top expressed in
	saccule; ; otic placode; ; supraoptic nucleus; ; ureter; ; otic vesicle; ; medullary collecting duct; ; renal corpuscle; ; vestibular sensory epithelium; ; primitive streak; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	low-density lipoprotein particle receptor binding; identical protein binding; molecular function;
Cellular component	plasma membrane; endoplasmic reticulum; cellular component;
Biological process	mesoderm development; protein folding; Wnt signaling pathway; phagocytosis; protein localization to cell surface; positive regulation of skeletal muscle acetylcholine-gated channel clustering;
	Sources:Amigo / QuickGO
Orthologs
	23184
	67943
	ENSG00000117899
	ENSMUSG00000038503
	Q14696
	Q9ERE7
	NM_015154
	NM_023403
	NP_055969
	NP_075892; NP_001361019
	Wikidata
View/Edit Human	View/Edit Mouse

LDLR chaperone MESD is a protein that in humans is encoded by the MESD gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038503 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
^ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
^ "Entrez Gene: MESDC2 mesoderm development candidate 2".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hsieh JC, Lee L, Zhang L, et al. (2003). "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity". Cell. 112 (3): 355–67. doi:10.1016/S0092-8674(03)00045-X. PMID 12581525.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Veltman IM, Vreede LA, Cheng J, et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)". Hum. Mol. Genet. 14 (14): 1955–63. doi:10.1093/hmg/ddi200. PMID 15917269.
Li Y, Lu W, He X, Bu G (2006). "Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd". FEBS Lett. 580 (22): 5423–8. doi:10.1016/j.febslet.2006.09.011. PMID 16989816.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117899 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7788527-5] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[pmid11247670-6] Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.

[entrez-7] "Entrez Gene: MESDC2 mesoderm development candidate 2".

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References

Further reading