SDK1

SDK1
Identifiers
Aliases	SDK1, sidekick cell adhesion molecule 1
External IDs	OMIM: 607216; MGI: 2444413; HomoloGene: 27395; GeneCards: SDK1; OMA:SDK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	4,269,000 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	142,201,341 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; decidua; ; tibial arteries; ; body of pancreas; ; sural nerve; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; gonad; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	otolith organ; ; utricle; ; Jacobson's organ; ; gastrula; ; internal carotid artery; ; genital tubercle; ; lens; ; external carotid artery; ; zygote; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	identical protein binding;
Cellular component	integral component of membrane; cell junction; synapse; membrane; plasma membrane;
Biological process	synapse assembly; cell adhesion; retina layer formation; regulation of dendritic spine development; behavioral response to cocaine; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell junction organization;
	Sources:Amigo / QuickGO
Orthologs
	221935
	330222
	ENSG00000146555
	ENSMUSG00000039683
	Q7Z5N4
	Q3UH53
	NM_001079653; NM_152744
	NM_177879
	NP_001073121; NP_689957
	NP_808547
	Wikidata
View/Edit Human	View/Edit Mouse

Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. ^[5] ^[6]

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily.^[7] The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146555 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039683 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Sidekick cell adhesion molecule 1". Retrieved 2018-05-31.
^ "OMIM: SIDEKICK CELL ADHESION MOLECULE 1; SDK1".
^ Yamagata, M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.

Yamagata M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.
Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (July 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J. Am. Soc. Nephrol. 15 (7): 1721–30. doi:10.1097/01.asn.0000128975.28958.c2. PMID 15213259.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients". J Psychiatr Res. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908.
Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE (August 2010). "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis". J. Biol. Chem. 285 (33): 25677–85. doi:10.1074/jbc.M110.133959. PMC 2919131. PMID 20562105.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ (October 2013). "A genome-wide association study for malignant mesothelioma risk". Lung Cancer. 82 (1): 1–8. doi:10.1016/j.lungcan.2013.04.018. PMID 23827383.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146555 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039683 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Sidekick cell adhesion molecule 1". Retrieved 2018-05-31.

[6] "OMIM: SIDEKICK CELL ADHESION MOLECULE 1; SDK1".

[7] Yamagata, M (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience. 13: 139. doi:10.3389/fnmol.2020.00139. PMC 7479261. PMID 32982686.

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Function

References

Further reading