Human genetic clustering
Human genetic clustering
Human genetic clustering refers to a wide range of scientific and statistical methods often used to characterize patterns and subgroups within studies of human genetic variation.
Clustering studies are thought to be valuable for characterizing the general structure of genetic variation among human populations, to better understand ancestral origins, evolutionary history, and personalized medicine. Since the mapping of the human genome, and with the availability of increasingly powerful analytic tools, cluster analyses have revealed a range of ancestral and migratory trends among human populations and individuals.[1]
The practice of defining clusters of human populations is largely arbitrary and variable, depending on the sampled data, genetic markers, and statistical methods applied to their construction. Nevertheless, studies of human genetic clustering have been implicated in discussions of race, ethnicity, and scientific racism, as some have controversially suggested that genetic clusters may represent genetically determined races.[2][3]
Genetic clustering algorithms and methods
Since at least 2001, a wide range of methods have been developed to assess the structure of human populations with the use of genetic data. Most commonly, genetic clusters can be derived by analysis of single nucleotide polymorphisms (SNPs), although other genetic data can be input and analyzed as well. Models for genetic clustering also vary by algorithms and programs used to process the data. Most methods for determining clusters can be categorized as model-based clustering methods or multidimensional summaries.[4][5] By processing a large number of SNPs (or other genetic marker data), both approaches to genetic clustering operate by identifying similarities among individual SNPs or haplotype tracts to reveal ancestral genetic similarities. ###add something about these being different but showing similar results, and cite Lawson & Falush.
Model-based clustering
Common model-based clustering algorithms include STRUCTURE, ADMIXTURE, and HAPMIX. These algorithms operate by finding the best fit for genetic data among an arbitrary or mathematically derived number of clusters, such that differences within clusters are minimized and differences between clusters are maximized. This clustering method is also referred to as "admixture inference," as individual genomes (or individuals within populations) can be characterized by the proportions of alleles linked to each cluster.[1]
Multidimensional summary statistics
Where model-based clustering aims to characterize proportions of cluster
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Applications to human genetic data
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(Lawson & Falush, 2012 (human genome diversity project section); Novembre & Ramachandran, 2011; Kalinowski, 2011 (criticism of STRUCTURE); Bamshad et al, 2004; Bamshad & Olson 2003 gets into alu polymorphisms in a clear way)
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Genetic clustering and race
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(Maglo et al 2016, Jorde & Wooding 2004; Bamshad articles)
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Related issues
</translate>Clusters vs. clines
Brief summary of human genetic variation?
Possibly this is a "see also" section?
- ^ a b Novembre, John; Ramachandran, Sohini (2011-09-22). "Perspectives on Human Population Structure at the Cusp of the Sequencing Era". Annual Review of Genomics and Human Genetics. 12 (1): 245–274. doi:10.1146/annurev-genom-090810-183123. ISSN 1527-8204.
- ^ Jorde, Lynn B; Wooding, Stephen P (2004-10-26). "Genetic variation, classification and 'race'". Nature Genetics. 36 (S11): S28 – S33. doi:10.1038/ng1435. ISSN 1061-4036.
- ^ Verfasser., Marks, Jonathan (Jonathan M.), 1955-. Is science racist?. ISBN 978-0-7456-8925-8. OCLC 1037867598.
{{cite book}}:|last=has generic name (help)CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link) - ^ Novembre, John; Ramachandran, Sohini (2011-09-22). "Perspectives on Human Population Structure at the Cusp of the Sequencing Era". Annual Review of Genomics and Human Genetics. 12 (1): 245–274. doi:10.1146/annurev-genom-090810-183123. ISSN 1527-8204.
- ^ Lawson, Daniel John; Falush, Daniel (2012-09-22). "Population Identification Using Genetic Data". Annual Review of Genomics and Human Genetics. 13 (1): 337–361. doi:10.1146/annurev-genom-082410-101510. ISSN 1527-8204.