User:Ecstaticreader/sandbox2
Mutational Hazard Hypothesis
The mutational hazard hypothesis is a non-adaptive theory for increased complexity in genomes[1]. Variation in complexity can be described by 2Neu, where Ne is effective population size, and u is mutation rate[2]. The basis of mutational hazard hypothesis is that each mutation for noncoding DNA imposes a fitness cost[3]. As complexity increases from prokaryotes to multicellular eukaryotes, effective population size decreases, subsequently increasing the strength of random genetic drift[1]. This allows noncoding DNA to proliferate without being removed by purifying selection[1].
- ^ a b c Lynch, Michael; Conery, John S. (2003-11-21). "The Origins of Genome Complexity". Science. 302 (5649): 1401–1404. doi:10.1126/science.1089370. ISSN 0036-8075.
- ^ Lynch, M. (2006-03-24). "Mutation Pressure and the Evolution of Organelle Genomic Architecture". Science. 311 (5768): 1727–1730. doi:10.1126/science.1118884. ISSN 0036-8075.
- ^ Lynch, Michael; Bobay, Louis-Marie; Catania, Francesco; Gout, Jean-François; Rho, Mina (2011-09-22). "The Repatterning of Eukaryotic Genomes by Random Genetic Drift". Annual Review of Genomics and Human Genetics. 12 (1): 347–366. doi:10.1146/annurev-genom-082410-101412. ISSN 1527-8204. PMC 4519033. PMID 21756106.
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