David J. Apple und Kategorie:Sportstätte in Charleroi: Unterschied zwischen den Seiten

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-'''David J Apple, MD''' (September 14, 1941 – August 18, 2011) was an ophthalmic pathologist who conducted research on the pathology of intraocular lens complications as well as ophthalmic surgery in general. He was a medical historian and biographer of Sir [[Harold Ridley (ophthalmologist)|Harold Ridley]], the inventor of the [[intraocular lens]] (IOL).
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-:''"He often stated that Harold Ridley changed the world. What we can say about David Apple is that he vastly improved the world that Harold Ridley changed"''<ref name="eyeworld">{{cite web|last=Fine|first=I. H.|title=A tribute to David J. Apple MD|url=http://www.eyeworld.org/article-a-tribute-to-david-j--apple--m-d-|publisher=Eyeworld}}</ref>
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-Apple founded the Center for Developing World Ophthalmology while he was Professor of Ophthalmology and Pathology at the Storm Eye Institute, Charleston SC..<ref name="AppleDavid">{{cite book|last=Apple|first=David J|title=Sir Harold Ridley and his fight for sight|year=2006|publisher=SLACK incorporated|isbn=1-55642-786-7}}</ref> His laboratory is an official [[WHO Collaborating Centres|Collaborating Center]] of the Prevention of Blindness Programme of the [[World Health Organization]] (WHO) and his research and meetings with WHO officials was instrumental in providing information to WHO on which type of IOL should be used in cataract surgery in developing countries.<ref name="AppleDavid" /><ref name="AppleDavid_a">{{cite journal|last=Apple|first=David J|author2=World Health Organization.|title=Use of intraocular lenses in cataract surgery in developing countries: Memorandum from a WHO meeting|journal=Bull WHO|year=1991|issue=69|pages=657–666.}}</ref>
+[[Kategorie:Sportstätte in der Provinz Hennegau|Charleroi]]
+[[Kategorie:Sport (Charleroi)]]
-==Background==
+[[Kategorie:Sportstätte nach Ort|Charleroi]]
-David Joseph Apple was born in [[Alton, Illinois]] on September 14, 1941 to Joseph and Margaret Bearden Apple. He had one brother, Robert born in 1937 who predeceased him in 1994.
-==Education and career==
-David Apple attended East Alton-Wood River High School located in [[Wood River, Illinois|Wood River, IL]] and graduated in 1959.<ref name="AppleDavid"/> He was a graduate of Northwestern University, [[University of Illinois College of Medicine]] and served his internship and residency in Pathology at [[Louisiana State University]]. In 1980 he completed his residency in ophthalmology at the [[University of Iowa]].  He was Assistant and subsequently Associate Professor of Ophthalmology under Morton F. Goldberg, MD at [[The University of Illinois Eye and Ear Infirmary]] and [[Abraham Lincoln School of Medicine]] in Chicago from 1971 to 1975.  He then completed his residency in Clinical Ophthalmology under Frederick C. Blodi, MD at the [[University of Iowa]] in 1979.<ref name="hosting-25037.tributes">{{cite web|title=Dr. David Joseph Apple Obituary|url=http://hosting-25037.tributes.com/show/David-Joseph-Apple-92226000}}</ref>
-Apple moved to South Carolina in 1988 to become Professor of Ophthalmology and Pathology, Professor and Chairman at the Storm Eye Institute, Medical University of South Carolina, Charleston.  He held the Pawek-Vallotton Chair of Biomedical Engineering and was Director of the Center or Research on Ocular Therapeutics and Biodevices until 2002. During his Chairmanship of the Department of Ophthalmology in Charleston from 1988 to 1996 he successfully led the effort to raise $8.8 million to complete a three-floor expansion and general renovation of the Eye Institute.  When he returned, he resigned from the Chair and became Director of Research for the Department.
-His laboratory in Charleston (and at later sites: Salt Lake City, Sullivan's Island and Heidelberg) was an official Collaborating Center of the WHO Prevention of Blindness Programme. His meeting with WHO Programme director Dr. Bjorn Thylefors of the Prevent Blindness Division, was instrumental in providing information to WHO on which type of IOL should be used in cataract surgery in developing countries <ref name="AppleDavid" /> and Apple wrote on the subject in 1991.<ref name="AppleDavid_a" />
-He returned to Utah in 2002 and transferred his Center for Intraocular Lens Research back to Salt Lake City, Utah: the city where he had begun his IOL-research.
-His career was distinguished by being the only ophthalmologist to have received the four most respected honours in his field:<ref name="hosting-25037.tributes" />
-)      The Life Achievement Honor Award by the American Academy of Ophthalmology (AAO)
-)      The AAO Ophthalmology Hall of Fame award in 2007
-)      The ASCRS Innovator's (Kelman) Award in 2005
-)      The Binkhorst Lecture Medal in 1988.<ref>{{cite web|title=David  J Apple a pioneer in ophthalmology and pathology dies at age 69|url=http://eyewiretoday.com/view.asp?20110830-david_j_apple_a_pioneer_in_opthalmology_and_pathology_dies_at_age_69|publisher=eyewiretoday.com}}</ref>
-In 1998 he became the only American to have been selected to give the European Guest Lecture at the [[Oxford Ophthalmological Congress]], held annually at the [[University of Oxford]]. He received the Senior Honor Award from the American Academy of Ophthalmology (AAO) in San Diego, CA.<ref name="hosting-25037.tributes" />
-He was elected in 2003 to the German Academy of Research in the Natural Sciences ''Deutsche Akademie der Naturforscher 'Leopoldina''.<ref>{{cite web|title=Mitgliederverzeichnis|url=http://www.leopoldina.org/de/mitglieder/mitgliederverzeichnis/member/980/|publisher=Leopoldina}}</ref><ref>{{cite journal|last=Kohnen|first=T|title=In Gedenken an David J. Apple, m.D. Weltweites Schaffen für die Augenheilkunde|journal=DGGI Aktuell|date=Maerz 2012|url=http://www.dgii.org/mitglieder/DGII_Aktuell_03-2012.pdf}}</ref> In co-authorship with Prof. Dr. Gottfried O.H. Naumann he published in 1990 ''Pathologie des Auges'', a German-language ocular pathology textbook. He published the English version as ''Pathology of the Eye'', in 1986.
-In 2006 Apple received an award from the [[The International Intra-Ocular Implant Club (IIIC)|International Intra-Ocular Implant Club]] - the IIIC Medal. His subject was "Sir Harold Ridley and his Fight for Sight" in the centenary year of Ridley's birth.
-At the 2012 meeting of the ESCRS in Milan, the Commemorative Lecture ''David J. Apple The Father of IOL Pathology'', was given by Steve Arshinoff MD of Canada:<ref>{{cite web|last=Arshinoff|first=S|title=David J Apple: The Father of IOL Pathology|url=http://www.escrs.org/milan2012/programme/david-apple.asp|work=Programme of the XXXth Congress of the ESCRS|publisher=ESCRS}}</ref>
-:"''David was the first IOL pathologist. He was an "IOL doctor’s doctor", as pathologists often are. He taught us to respect our heritage – those whose struggles to innovate enriched our abilities to care for our patients, but to remember: '''Most innovations fail.''' He also taught us to be cautious with the latest innovation, and to study the long-term effects of each new IOL or gadget, before fully accepting it."''
-:
-==The Apple Korps==
-During his lifetime Dr Apple trained over 200 students and doctors, calling this group his "Apple Korps".  His lab was international: with staff and research fellows being selected from all over the world.
-==Sir Harold Ridley==
-In Salt Lake City during the 1980s, Apple started to study intraocular lenses (IOLs), including those explanted lenses which had been removed (explanted) from the eye,  following complications. His scientific papers on IOLs<ref>{{cite journal|last=Apple DJ, Mamalis N, Loftfield K, et al:|title=Complications of intraocular lenses: A historical and histopathological review|journal=Surv Ophthalmol|year=1984|volume=29|pages=1–54|doi=10.1016/0039-6257(84)90113-9|pmid=6390763|first1=DJ|last2=Mamalis|first2=N|last3=Loftfield|first3=K|last4=Googe|first4=JM|last5=Novak|first5=LC|last6=Kavka-Van Norman|first6=D|last7=Brady|first7=SE|last8=Olson|first8=RJ|issue=1}}</ref><ref>{{cite journal|last=Apple DJ, Solomon KD, Tetz MR, et al|title=Posterior capsule opacification|journal=Surv Ophthalmol|year=1992|volume=37|pages=73–116|doi=10.1016/0039-6257(92)90073-3|pmid=1455302|first1=David J.|last2=Solomon|first2=Kerry D.|last3=Tetz|first3=Manfred R.|last4=Assia|first4=Ehud I.|last5=Holland|first5=Elizabeth Y.|last6=Legler|first6=Ulrich F.C.|last7=Tsai|first7=Julie C.|last8=Castaneda|first8=Victoria E.|last9=Hoggatt|first9=Judy P.|last10=Kostick|first10=Alexandra M.P.|issue=2|display-authors=8}}</ref> attracted the interest of [[Harold Ridley (ophthalmologist)|Harold Ridley]], the British inventor of the intraocular lens. Through mutual contacts Ridley asked David Apple to visit him at his home near Salisbury in England. Thus began a friendship which did much to legitimise and restore Ridley's reputation as the inventor of the IOL and Apple's reputation as the foremost researcher in IOL research.<ref name="Mamalis">{{cite journal|last=Mamalis|first=N|coauthors=Rosen ES, Koch DD, Kohnen T, Dupps WJ Jr, Obstbaum SA.|title=In remembrance|journal=J Cataract Refract Surg|year=2011|volume=11|pages=1921–1922|doi=10.1016/j.jcrs.2011.09.025|issue=11}}</ref>
-==Personal life==
-Dr. Apple married Ann Addlestone In 1995 and became stepfather to Scott E. Kabat and Jacqueline B. Kabat. Through his brother, Robert V. Apple's family, he had one nephew: Lee B. Apple and two nieces: Rana Apple Ford and Dione Apple Badkar, all from California.
-In the late 1990s he developed a serious illness (self-diagnosed - correctly - as a metastatic cancer at the base of the tongue.) Between 1999 and 2011 he had numerous bouts of pneumonia and was frequently hospitalised - most seriously with a cerebral vascular stroke two years after his move to Salt Lake City.
-Besides ophthalmology, Dr. Apple was passionate about classical music - he served on the Board of the Charleston Symphony, the Board of the Charleston Ballet Theatre and was active in [[Chamber Music Charleston]]. He was an amateur military historian, specialising in  [[World War II]] and the  [[US Civil War]]. In a tribute I. Howard Fine MD wrote affectionately of his friend,
-:''On a personal level, David was a good friend and a delightful person with a subtle sense of humor. He had a passion for history, especially the history of science, the Civil War, and music. He liked to inform ophthalmologists that Johann Sebastian Bach died shortly after his health began to deteriorate as a result of a botched cataract surgery by an itinerant surgeon. David reminded us that the first hostilities of the Civil War took place in Charleston, his home, with the Confederate bombardment of Fort Sumter. He had an enormous corpus of knowledge and was a great lover of music. While living in Charleston, he served on the boards of the Charleston Symphony and the Charleston Ballet and was active in Chamber Music Charleston. He was pleased that his home was the model for one of the houses on Catfish Row, the stage setting for the American opera "Porgy and Bess." He loved to travel, was fluent in German, and had a special affection for his dachshunds. His wife, Ann, was the love of his life and a favorite of their friends throughout the world. A few years after their marriage, David was diagnosed with a malignancy, which required surgery, chemotherapy, and radiation therapy. Ann nurtured, maintained, and cared for him magnificently over the ensuing years as he dealt with the chronic pain and the terrible side effects of his surgery and anti-cancer treatments' <ref name="eyeworld" />
-David Apple died on the afternoon of August 18, 2011 in Charleston SC,  The funeral service was on Sunday, August 21, 2011 at the Beth Elohim Temple with interment at Beth Elohim Cemetery, Huguenin Avenue. Charleston SC.<ref name="hosting-25037.tributes" />
-==Apple's legacy==
-:'''Miyake-Apple technique''' This method of sectioning the cadaver eye was initially developed by Kansatu Miyake MD and refined by David Apple. The eye is disected posterior to the posterior lens capsule and the anterior segment is mounted above a camera which allows observation of the IOL in-situ in the capsule from a posteior view: thus as though looking out on the world through the lens and cornea.<ref>{{cite journal|last=Apple D, Lim E, Morgan R, et al.|title=Preparation and study of human eyes obtained postmortem with the Miyake posterior photographic technique|journal=Ophthalmology|year=1990|volume=97|pages=810–816|pmid=2374686|first1=DJ|last2=Lim|first2=ES|last3=Morgan|first3=RC|last4=Tsai|first4=JC|last5=Gwin|first5=TD|last6=Brown|first6=SJ|last7=Carlson|first7=AN|issue=6|doi=10.1016/s0161-6420(90)32507-1}}</ref>  Using this technique, Apple and his colleagues were able to analyse the performance of IOLs made of different biomaterials and different lens designs.<ref>{{cite journal|last=Vargas|first=L G|author2=Peng Q |author3=Apple DJ |author4=Escobar-Gomez M |author5=Pandey SK |author6=Arthur SN |author7=Hoddinott DS |author8=Schmidbauer JM. |title=Evaluation of 3 modern single-piece foldable intraocular lenses: clinicopathological study of posterior capsule opacification in a rabbit model|journal=J Cataract Refract Surg.|date=Jul 2002|volume=28|series=(7)|pages=1241–50.|pmid=12106735|doi=10.1016/S0886-3350(02)01216-6|issue=7}}</ref>
-:
-:'''The Apple Korps''' In what may prove a most enduring legacy Dr Apple trained over 200 students and doctors at his Charleston and Salt Lake City sites and these "students" are now in key positions in ophthalmic education and practice throughout the world.'''<ref name="AppleDavid" />
-:'''Research Laboratory'''At the time of his death, Apple's laboratory was in Sullivan's Island near Charleston, South Carolina.  In 2012 the '''David J Apple International Laboratory for Ocular Pathology''' was re-located and re-established at [[Heidelberg University]] in the University Eye Department. Professor Gerd U. Auffarth, Eye Department Chairman - a former research fellow in the Apple Korps - outlined his plans to create an international laboratory for research on intraocular ophthalmic devices, thus continuing and extending the research work initiated by David Apple.<ref>{{cite web|last=Auffarth|first=Gerd U|title=Welcome to the new Apple Lab!|url=http://djapplelab.com/welcome/|accessdate=27 January 2013}}</ref>  The laboratory in Heidelberg holds Professor Apple’s archives, historical laboratory samples and correspondence.  <ref>{{cite web|title=David-Apple Laboratory launched at University of Heidelberg|url=http://www.healio.com/ophthalmology/ophthalmic-business/news/online/%7BE924728B-4058-4570-8B61-39FD5F67F7F8%7D/David-Apple-Laboratory-launched-at-University-of-Heidelberg|publisher=www.healio.com/ophthalmology/ophthalmic-business/news/online/}}</ref>
-:'''Amon-Apple Enhanced Square Edge''' is a barrier to cell proliferation at the haptic-optic junction of single-piece IOLs. The Edge was first developed by Peter Toop and Mike Ring - both engineers at the IOL manufacturer Rayner Intraocular Lenses Limited in 2003, after taking advice from Prof. Michael Amon,  Ophthalmic Surgeon in Vienna, Austria together with David Apple. The design feature is intended to reduce Posterior Capsular Opacification (PCO) by creating an insurmountable physical barrier to cell migration from the haptic surface onto the optic surface of the lens. Both Amon and Apple recognised in 2002 (through respectively a laboratory study on Centerflex minus power lenses and a clinical study of the regular power Centerflex lenses<ref>{{cite journal|last=Vargas|first=LG|author2=Izak AM |author3=Apple DJ |author4=Werner L |author5=Pandey SK |author6=Trivedi RH. |title=Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification|journal=J Cataract Refract Surg.|date=Aug 2003|volume=29|series=(8)|pages=1613–20.|pmid=12954315|doi=10.1016/S0886-3350(03)00215-3|issue=8}}</ref> ) that all modern single-piece, injectable IOLs  in 2002 had a weakness (which Apple termed the "Achilles heel") at the haptic-optic junction: where there is no square edge and thus an incomplete barrier to PCO.<ref>{{cite web|title=Enhanced Square Edge Technology|url=http://www.rayner.com/products/technology/ESET|publisher=Rayner Intraocular Lenses Limited}}</ref>'''<ref name="AppleDavid" />
-==Writing==
-His publications concerning the IOL studies and his review of the history of IOLs led to the publication of two textbooks: ''Evolution of Intraocular Lenses''<ref>{{cite book|last=Apple D J, Geiser S C, Isenberg R A|title=Evolution of Intraocular Lenses|year=1985|publisher=University of Utah Printing Services|location=Salt Lake City}}</ref> in 1985 and ''Intraocular Lenses. Evolution, Designs, Complications, and Pathology''<ref>{{cite book|last=Apple, DJ. Kincaid MC, Mamalis N, Olson RJ|title=Intraocular Lenses. Evolution, Designs, Complications, and Pathology.|year=1989|publisher=Williams & Wilkins.|location=Baltimore}}</ref> in 1989.
-Dr. Apple's 2006 biography, ''Sir Harold Ridley and his Fight for Sight: He changed the world so that we may better see it''<ref name="AppleDavid" /> came about when [[Harold Ridley (ophthalmologist)|Harold Ridley]], the British inventor of the intraocular lens, asked David Apple to be his biographer.<ref>{{cite news|last=Robinson|first=Katrina|title=Dr David J. Apple writes notable book following cancer diagnosis|url=http://www.postandcourier.com/article/20090326/ARCHIVES/303269864|newspaper=The Post & Courier|date=March 26, 2009}}</ref>
-Dr. Apple presented more than 1,400 scientific lectures, 168 scientific posters, and more than 60 exhibits and videos.  He authored 566 scientific publications, including 23 textbooks, 71 chapters in textbooks.<ref name="hosting-25037.tributes" />
-==See also==
-*[[Harold Ridley (ophthalmologist)]]
-*[[Intraocular lens]]
-==References==
-{{Reflist}}
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-{{Persondata
-| NAME              = Apple, David J.
-| ALTERNATIVE NAMES =
-| SHORT DESCRIPTION = American ophthalmologist
-| DATE OF BIRTH     = September 14, 1941
-| PLACE OF BIRTH    =
-| DATE OF DEATH     = August 18, 2011
-| PLACE OF DEATH    =
-}}
-{{DEFAULTSORT:Apple, David J.}}
-[[Category:1941 births]]
-[[Category:2011 deaths]]
-[[Category:People from Charleston, South Carolina]]
-[[Category:American ophthalmologists]]
-[[Category:American pathologists]]
-[[Category:American medical historians]]
-[[Category:People from Alton, Illinois]]