2C-G

2C-G

Clinical data
Other names	2C-G-0; 2,5-Dimethoxy-3,4-dimethylphenethylamine; 3,4-Dimethyl-2,5-dimethoxyphenethylamine
Legal status
Legal status	In general Unscheduled
Identifiers
IUPAC name 2-(2,5-dimethoxy-3,4-dimethylphenyl)ethan-1-amine
CAS Number	207740-18-9 Y
PubChem CID	22238091
ChemSpider	21106224 Y
UNII	DTG7FMO01J
ChEMBL	ChEMBL127202 Y
CompTox Dashboard (EPA)	DTXSID70174848
Chemical and physical data
Formula	C12H19NO2
Molar mass	209.289 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc1c(C)c(C)c(cc1CCN)OC
InChI InChI=1S/C12H19NO2/c1-8-9(2)12(15-4)10(5-6-13)7-11(8)14-3/h7H,5-6,13H2,1-4H3 Y Key:NFOHGLKGLZIHJQ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

2C-G, or 2C-G-0, also known as 3,4-dimethyl-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C-series. First synthesized by Alexander Shulgin, it is sometimes used as an entheogen. It has structural and pharmacodynamic properties similar to 2C-D and Ganesha. Like many of the phenethylamines in PiHKAL, 2C-G and its homologs have only been taken by Shulgin and a small test group, making it difficult to ensure completeness when describing effects.

Use and effects

In Shulgin's book PiHKAL, the dosage range is listed as 20 to 35 mg. Effects are similar to the related Ganesha, and are extremely long lasting; the duration is 18 to 30 hours. Visual effects are muted or absent, and it is described in PiHKAL as an "insight-enhancer". Unlike other members of the 2C-series, 2C-G is nearly as potent as its amphetamine form.

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

2C-G is 3,4-dimethyl-2,5-dimethoxyphenethylamine, with the formula C
₁₂H
₁₉NO
₂.

Homologues

Several homologues of 2C-G were also synthesized by Alexander Shulgin. These include 2C-G-3, 2C-G-5, and 2C-G-N. Some, such as 2C-G-1, 2C-G-2, 2C-G-4, and 2C-G-6 are possible to synthesize in principle but impossible or extraordinarily difficult to do so in practice.

Compound	Details	Structure
2C-G-1	CAS: 2888537-47-9 The synthesis of this compound has not been reported, but it is described prophetically in WO2022271982
2C-G-2	CAS: 2888537-48-0 The synthesis of this compound has not been reported, but it is described prophetically in WO2022271982
2C-G-3	CAS: 207740-19-0 Dosage: 16–25 mg Duration: 12–24 hours Effects: Some visual effects. General euphoria with an underlying sense of paranoia.
2C-G-4	CAS: 952006-59-6 Synthesized but not tested.
2C-G-5	CAS: 207740-20-3 Dosage: 10–16 mg Duration: 32–48 hours Effects: Similar to 2C-B for some users. General euphoria (sometimes followed by irritability), often leading to tiredness (likely due to duration).
2C-G-6	CAS: 2888537-49-1 The synthesis of this compound has not been reported, but it is described prophetically in WO2022271982
2C-G-N	CAS: 207740-21-4 Dosage: 20–40 mg Duration: 20–30 hours Effects: Stimulation similar to that caused by amphetamines. General sense of unease or unfriendliness for most. 2C-G-N is sometimes called 2C-NPH due to the naphthalene portion of the molecule.

Society and culture

Legal status

Canada

As of October 31, 2016; 2C-G is a controlled substance (Schedule III) in Canada.

United Kingdom

2C-G and all other compounds featuring in PiHKAL are Class A drugs in the United Kingdom.

United States

In the United States 2C-G is considered a Schedule 1 controlled substance as a positional isomer of 2C-E and 2,5-Dimethoxy-4-methylamphetamine (DOM).

See also

• 2C (psychedelics)
• Ganesha
• DOTMA

External links

• 2C-G PiHKAL entry: Erowid and Isomer Design
• 2C-G-3 PiHKAL entry: Erowid and Isomer Design
• 2C-G-4 PiHKAL entry: Erowid and Isomer Design
• 2C-G-5 PiHKAL entry: Erowid and Isomer Design
• 2C-G-N PiHKAL entry: Erowid and Isomer Design