GPAT4

GPAT4
Identifiers
Aliases	GPAT4, 1-AGPAT 6, LPAAT-zeta, LPAATZ, TSARG7, AGPAT6, glycerol-3-phosphate acyltransferase 4
External IDs	OMIM: 608143; MGI: 2142716; HomoloGene: 32425; GeneCards: GPAT4; OMA:GPAT4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	41,625,001 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,698,362 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; right adrenal cortex; ; gastrocnemius muscle; ; left adrenal gland; ; left adrenal cortex; ; smooth muscle tissue; ; appendix;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; ventricular zone; ; neural layer of retina; ; brown adipose tissue; ; right kidney; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; acyltransferase activity; glycerol-3-phosphate O-acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; lipid biosynthetic process; acyl-CoA metabolic process; regulation of multicellular organism growth; lipid metabolism; fatty acid metabolic process; mammary gland development; diacylglycerol metabolic process; phospholipid biosynthetic process; glandular epithelial cell maturation; phosphatidylcholine biosynthetic process; metabolism; lactation; triglyceride metabolic process; triglyceride biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	137964
	102247
	ENSG00000158669
	ENSMUSG00000031545
	Q86UL3
	Q8K2C8
	NM_178819; NM_001363197; NM_001363198
	NM_018743
	NP_848934; NP_001350126; NP_001350127
	NP_061213
	Wikidata
View/Edit Human	View/Edit Mouse

Glycerol-3-phosphate acyltransferase 4 is a protein that in humans is encoded by the GPAT4 gene. ^[5]

Function

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158669 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031545 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Glycerol-3-phosphate acyltransferase 4". Retrieved 2018-10-10.

Tan XJ, Huang ZP, Li LY, Nie DS, Zhong CG, Fu JJ, Lu GX (April 2006). "Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis". Yi Chuan Xue Bao. 33 (4): 294–303. doi:10.1016/S0379-4172(06)60054-1. PMID 16625827.
Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G (April 2008). "AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase". J. Biol. Chem. 283 (15): 10048–57. doi:10.1074/jbc.M708151200. PMC 2442282. PMID 18238778.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Shan D, Li JL, Wu L, Li D, Hurov J, Tobin JF, Gimeno RE, Cao J (July 2010). "GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis". J. Lipid Res. 51 (7): 1971–81. doi:10.1194/jlr.M006304. PMC 2882735. PMID 20181984.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158669 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031545 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Glycerol-3-phosphate acyltransferase 4". Retrieved 2018-10-10.

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Function

References

Further reading