TRPM2
Template:PBB Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a human gene. The gene is highly expressed in the brain and was implicated by both genetic linkage studies in families [1] and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression). [2][3]
See also
References
- ^ Gurling H.M. Chromosome 21 workshop, Psychiatric Genetics, 1998 Summer;8(2):109-13
- ^ McQuillin A, Bass NJ, Kalsi G, Lawrence J, Puri V, Choudhury K, Detera-Wadleigh SD, Curtis D, Gurling HM.Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Molecular Psychiatry. 2006 Feb;11(2):134-42
- ^ Xu C, Macciardi F, Li PP, Yoon IS, Cooke RG, Hughes B, Parikh SV, McIntyre RS, Kennedy JL, Warsh JJ.: Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 5;141B(1):36-43
Further reading
External links
- "Transient Receptor Potential Channels: TRPM2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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