Module talk:Infobox gene/testcases

SPI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PUE
Identifiers
Aliases	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10
External IDs	OMIM: 165170; MGI: 98282; HomoloGene: 2346; GeneCards: SPI1; OMA:SPI1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,378,547 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,946,101 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lung; ; upper lobe of left lung; ; spleen; ; blood; ; bone marrow cells; ; appendix; ; right coronary artery; ; lymph node;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; mesenteric lymph nodes; ; stroma of bone marrow; ; spleen; ; blood; ; medulla of thymus; ; embryo; ; lip; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity; NFAT protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding;
Cellular component	nucleus; nucleoplasm; transcription regulator complex;
Biological process	myeloid leukocyte differentiation; regulation of transcription, DNA-templated; cellular response to ethanol; somatic stem cell population maintenance; lymphocyte differentiation; regulation of erythrocyte differentiation; myeloid dendritic cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of MHC class II biosynthetic process; lymphoid progenitor cell differentiation; transcription, DNA-templated; macrophage differentiation; anatomical structure regression; negative regulation of histone H4 acetylation; negative regulation of gene expression, epigenetic; vasculature development; granulocyte differentiation; apoptotic process involved in blood vessel morphogenesis; histone H3 acetylation; erythrocyte differentiation; hypermethylation of CpG island; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; pri-miRNA transcription by RNA polymerase II; cell differentiation; interleukin-6-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6688
	20375
	ENSG00000066336
	ENSMUSG00000002111
	P17947
	P17433
	NM_001080547; NM_003120
	NM_011355; NM_001378898; NM_001378899
	NP_001074016; NP_003111
	NP_035485; NP_001365827; NP_001365828
	Wikidata
View/Edit Human	View/Edit Mouse

RELN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ddu, 2e26, 2DDU, 2E26, 3A7Q
Identifiers
Aliases	RELN, LIS2, PRO1598, RL, reelin, ETL7
External IDs	OMIM: 600514; MGI: 103022; HomoloGene: 3699; GeneCards: RELN; OMA:RELN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	103,989,658 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	22,549,700 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; cerebellar vermis; ; cerebellar hemisphere; ; paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; spinal ganglia; ; trigeminal ganglion; ; endothelial cell; ; tibial nerve; ; pons;
	Top expressed in
	ciliary body; ; cerebellar vermis; ; lobe of cerebellum; ; iris; ; olfactory bulb; ; sciatic nerve; ; endothelial cell of lymphatic vessel; ; superior colliculus; ; paraventricular nucleus of hypothalamus; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; peptidase activity; hydrolase activity; serine-type peptidase activity; lipoprotein particle receptor binding; very-low-density lipoprotein particle receptor binding;
Cellular component	cytoplasm; dendrite; plasma membrane; extracellular region; extracellular space; membrane; extracellular matrix; neuron projection;
Biological process	NMDA glutamate receptor clustering; positive regulation of lateral motor column neuron migration; dendrite development; proteolysis; cerebral cortex development; lateral motor column neuron migration; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of TOR signaling; long-term memory; multicellular organism development; receptor localization to synapse; postsynaptic density protein 95 clustering; ventral spinal cord development; protein localization to synapse; forebrain development; long-term potentiation; regulation of gene expression; layer formation in cerebral cortex; cell migration; learning; associative learning; cell adhesion; hippocampus development; spinal cord patterning; cerebral cortex tangential migration; positive regulation of peptidyl-tyrosine phosphorylation; glial cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of excitatory postsynaptic potential; positive regulation of CREB transcription factor activity; positive regulation of protein kinase activity; modulation of chemical synaptic transmission; positive regulation of AMPA receptor activity; brain development; central nervous system development; response to pain; positive regulation of synapse maturation; positive regulation of long-term synaptic potentiation; cell morphogenesis involved in differentiation; neuron migration; positive regulation of neuron projection development; positive regulation of small GTPase mediated signal transduction; positive regulation of synaptic transmission, glutamatergic; regulation of behavior; positive regulation of dendritic spine morphogenesis; reelin-mediated signaling pathway; regulation of NMDA receptor activity; positive regulation of protein tyrosine kinase activity; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5649
	19699
	ENSG00000189056
	ENSMUSG00000042453
	P78509
	Q60841
	NM_173054; NM_005045
	NM_011261; NM_001310464
	NP_005036; NP_774959
	NP_001297393; NP_035391
	Wikidata
View/Edit Human	View/Edit Mouse

RELN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ddu, 2e26, 2DDU, 2E26, 3A7Q
Identifiers
Aliases	RELN, LIS2, PRO1598, RL, reelin, ETL7
External IDs	OMIM: 600514; MGI: 103022; HomoloGene: 3699; GeneCards: RELN; OMA:RELN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	103,989,658 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	22,549,700 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; cerebellar vermis; ; cerebellar hemisphere; ; paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; spinal ganglia; ; trigeminal ganglion; ; endothelial cell; ; tibial nerve; ; pons;
	Top expressed in
	ciliary body; ; cerebellar vermis; ; lobe of cerebellum; ; iris; ; olfactory bulb; ; sciatic nerve; ; endothelial cell of lymphatic vessel; ; superior colliculus; ; paraventricular nucleus of hypothalamus; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; peptidase activity; hydrolase activity; serine-type peptidase activity; lipoprotein particle receptor binding; very-low-density lipoprotein particle receptor binding;
Cellular component	cytoplasm; dendrite; plasma membrane; extracellular region; extracellular space; membrane; extracellular matrix; neuron projection;
Biological process	NMDA glutamate receptor clustering; positive regulation of lateral motor column neuron migration; dendrite development; proteolysis; cerebral cortex development; lateral motor column neuron migration; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of TOR signaling; long-term memory; multicellular organism development; receptor localization to synapse; postsynaptic density protein 95 clustering; ventral spinal cord development; protein localization to synapse; forebrain development; long-term potentiation; regulation of gene expression; layer formation in cerebral cortex; cell migration; learning; associative learning; cell adhesion; hippocampus development; spinal cord patterning; cerebral cortex tangential migration; positive regulation of peptidyl-tyrosine phosphorylation; glial cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of excitatory postsynaptic potential; positive regulation of CREB transcription factor activity; positive regulation of protein kinase activity; modulation of chemical synaptic transmission; positive regulation of AMPA receptor activity; brain development; central nervous system development; response to pain; positive regulation of synapse maturation; positive regulation of long-term synaptic potentiation; cell morphogenesis involved in differentiation; neuron migration; positive regulation of neuron projection development; positive regulation of small GTPase mediated signal transduction; positive regulation of synaptic transmission, glutamatergic; regulation of behavior; positive regulation of dendritic spine morphogenesis; reelin-mediated signaling pathway; regulation of NMDA receptor activity; positive regulation of protein tyrosine kinase activity; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	5649
	19699
	ENSG00000189056
	ENSMUSG00000042453
	P78509
	Q60841
	NM_173054; NM_005045
	NM_011261; NM_001310464
	NP_005036; NP_774959
	NP_001297393; NP_035391
	Wikidata
View/Edit Human	View/Edit Mouse

RELN

Module:Infobox gene →

Module:Infobox gene/sandbox →

SPI1

Module:Infobox gene →

Module:Infobox gene/sandbox →

SPI1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1PUE

Identifiers

Aliases

SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10

External IDs

OMIM: 165170; MGI: 98282; HomoloGene: 2346; GeneCards: SPI1; OMA:SPI1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p11.2	Start	47,354,860 bp^[1]
Band	11p11.2	End	47,378,547 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 E1\|2 50.44 cM	Start	90,912,735 bp^[2]
Band	2 E1\|2 50.44 cM	End	90,946,101 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

monocyte

right lung

upper lobe of left lung

spleen

blood

bone marrow cells

appendix

right coronary artery

lymph node

Top expressed in

granulocyte

tibiofemoral joint

mesenteric lymph nodes

stroma of bone marrow

spleen

blood

medulla of thymus

embryo

lip

ankle joint

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding RNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity NFAT protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding
Cellular component	nucleus nucleoplasm transcription regulator complex
Biological process	myeloid leukocyte differentiation regulation of transcription, DNA-templated cellular response to ethanol somatic stem cell population maintenance lymphocyte differentiation regulation of erythrocyte differentiation myeloid dendritic cell differentiation negative regulation of transcription by RNA polymerase II negative regulation of MHC class II biosynthetic process lymphoid progenitor cell differentiation transcription, DNA-templated macrophage differentiation anatomical structure regression negative regulation of histone H4 acetylation negative regulation of gene expression, epigenetic vasculature development granulocyte differentiation apoptotic process involved in blood vessel morphogenesis histone H3 acetylation erythrocyte differentiation hypermethylation of CpG island positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II pri-miRNA transcription by RNA polymerase II cell differentiation interleukin-6-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6688


20375

Ensembl


ENSG00000066336


ENSMUSG00000002111

UniProt


P17947


P17433

RefSeq (mRNA)


NM_001080547 NM_003120


NM_011355 NM_001378898 NM_001378899

RefSeq (protein)


NP_001074016 NP_003111


NP_035485 NP_001365827 NP_001365828

Location (UCSC)

Chr 11: 47.35 – 47.38 Mb

Chr 2: 90.91 – 90.95 Mb

PubMed search

^[9]

^[10]

Wikidata

View/Edit Human

View/Edit Mouse

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l GRCh38: Ensembl release 89: ENSG00000189056 – Ensembl, May 2017 Cite error: The named reference "refGRCh38Ensembl" was defined multiple times with different content (see the help page).
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l GRCm38: Ensembl release 89: ENSMUSG00000042453 – Ensembl, May 2017 Cite error: The named reference "refGRCm38Ensembl" was defined multiple times with different content (see the help page).
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l GRCh38: Ensembl release 89: ENSG00000189056 – Ensembl, May 2017 Cite error: The named reference "refGRCh38Ensembl" was defined multiple times with different content (see the help page).

[refGRCm38Ensembl-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l GRCm38: Ensembl release 89: ENSMUSG00000042453 – Ensembl, May 2017 Cite error: The named reference "refGRCm38Ensembl" was defined multiple times with different content (see the help page).

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[7] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[8] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[9] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[10] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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