Automated Imaging Microscope System

The Automated Imaging Microscope System (AIMS) was developed by scientists at the Aging Research Centre (ARC) and the University of California, Berkeley. Steven A. Garan, was the lead scientists that developed the AIMS system along with Warren Freitag and Jason Neudorf, and many journals articles have been published about the system and the results that it produced. Since the completion of the first version in 1998, newer versions were developed, with the final version being completed in 2006.

Publications

• Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 141-142

• Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction. Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 11-12.

• Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice. Int J Dev Neurosci. 2006 Dec 26

• Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice. Int J Dev Neurosci. 2006 Nov;24(7):431-6.

• A study of insulin-like growth factor-I receptor immunoreactivity in the supraoptic nucleus of young and old female B6D2F1 mice. Experimental Biology, April 2006, 357.5

• Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice, Neuro Endocrinol Lett. 2005 Jun;26(3):197-203.

• A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice, Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1771

• Automated Imaging Microscope System, Linux Journal 2000, Issue 70, Februrary, Page 32-35

See also

• Aging Research Centre

External links

• Aging Research Centre: http://www.arclab.org
• Automated Imaging Microscope System (AIMS) http://www.arclab.org/AIMS/